Phase 1 trials with HA22, a new more active form of BL22 have been initiated in CLL and Hairy Cell Leukemia.

A phase 2 trial with immunotoxin BL22 that targets CD22 on Hairy Cell Leukemia has been completed. 32 patients have been treated and about half of these patients have under gone complete remissions.

A phase 1 trial with BL22 in pediatric ALL is open in collaboration with Dr. Alan Wayne, P.O.B. The current dose level is 40 microgram/kg Q.O.D. x 6. No major toxicities have occurred and anti-tumor activity has been observed.

Two phase 1 trials with immunotoxin SS1P given by continuous infusion or Q.O.D. x 3 for mesothelioma, pancreatic cancer and ovarian cancer have been completed. Several minor responses were observed. A phase 2 trial combining SS1P with chemotherapy is planned to open in late 2007.

A phase 1 trial in CLL with immunotoxin LMB 2 targeting CD25 is open. Also a phase 1 trial in CTCL is open.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010020-12
Application #
7592623
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2007
Total Cost
$819,464
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Du, Xing; Beers, Richard; Fitzgerald, David J et al. (2008) Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. Cancer Res 68:6300-5
Onda, Masanori; Beers, Richard; Xiang, Laiman et al. (2008) An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci U S A 105:11311-6
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