Abstract

Analysis of whole genomes using mapping by admixture linkage disequilibrium (MALD), and of candidate genes requires an appropriate set of markers and the ability to accurately genotype hundreds to thousands of patients with hundreds to thousands of markers. Utilizing the laboratory we have developed at the Laboratory of Genomic Diversity (LGD) has allowed determination and publication of a MALD map for disease gene discovery in African Americans. Our collaborators have now used that map and method for gene localization in prostate cancer and multiple sclerosis. Ongoing efforts in the laboratory are applying the MALD technology to HIV/AIDS, Hepatitis C virus (HCV), focal segmental glomerulosclerosis, and end-stage renal disease.The laboratory has also undertaken candidate gene analysis. One success from this year was the publication of a incidence density sampling approach to HIV-1 infection. In this study we examined genes in the CCR5 viral entry pathway. An invited commentary was glowing in pointing to the approach as the way genetic epidemiological studies regarding viral infection should be designed and performed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010270-10
Application #
7338291
Study Section
(LGD)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Chretien, J-P; Coresh, J; Berthier-Schaad, Y et al. (2006) Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans. J Med Genet 43:917-23
Liu, Yongmei; Berthier-Schaad, Yvette; Fallin, Margaret D et al. (2006) IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort. J Am Soc Nephrol 17:863-70
Laud, K; Marian, C; Avril, M F et al. (2006) Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. J Med Genet 43:39-47
Shrestha, Sadeep; Strathdee, Steffanie A; Galai, Noya et al. (2006) Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. J Infect Dis 193:16-26
Zhang, Lin; Kao, W H Linda; Berthier-Schaad, Yvette et al. (2006) Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. J Am Soc Nephrol 17:2285-92
Liu, Yongmei; Berthier-Schaad, Yvette; Fink, Nancy E et al. (2005) Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. Am J Kidney Dis 46:78-85
Oleksyk, T K; Thio, C L; Truelove, A L et al. (2005) Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes Immun 6:347-57
Shrestha, Sadeep; Smith, Michael W; Beaty, Terri H et al. (2005) Theory and methodology for utilizing genes as biomarkers to determine potential biological mixtures. Ann Epidemiol 15:29-38
Smith, Michael W; O'Brien, Stephen J (2005) Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet 6:623-32
Oleksyk, T K; Goldfarb, L G; Sivtseva, T et al. (2004) Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. Eur J Immunogenet 31:121-8

Showing the most recent 10 out of 13 publications