Abstract

Genome-wide association analysis with a dense marker set, mapping by admixture linkage disequilibrium (MALD) with ancestry informative markers, and examination of candidate gene analysis each requires a high-throughput genotyping laboratory. Utilizing the core laboratory we have developed at the Laboratory of Genomic Diversity (LGD) has allowed determination and publication of a MALD map for disease gene discovery in African Americans. Our collaborators have now used that map and the MALD method for gene identification in prostate cancer and IL-6 levels along with gene localization in multiple sclerosis. Ongoing efforts in our laboratory are applying the MALD technology to HIV/AIDS, Hepatitis C virus (HCV), focal segmental glomerulosclerosis, and end-stage renal disease. The laboratory has also undertaken candidate gene analysis for HIV-1, HCV, HBV and cardiovascular disease complications of end-stage renal disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010270-12
Application #
7732979
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2008
Total Cost
$287,309
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Chretien, J-P; Coresh, J; Berthier-Schaad, Y et al. (2006) Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein(a) level elevation in African Americans compared with European Americans. J Med Genet 43:917-23
Liu, Yongmei; Berthier-Schaad, Yvette; Fallin, Margaret D et al. (2006) IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort. J Am Soc Nephrol 17:863-70
Laud, K; Marian, C; Avril, M F et al. (2006) Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. J Med Genet 43:39-47
Shrestha, Sadeep; Strathdee, Steffanie A; Galai, Noya et al. (2006) Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. J Infect Dis 193:16-26
Zhang, Lin; Kao, W H Linda; Berthier-Schaad, Yvette et al. (2006) Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. J Am Soc Nephrol 17:2285-92
Liu, Yongmei; Berthier-Schaad, Yvette; Fink, Nancy E et al. (2005) Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohort. Am J Kidney Dis 46:78-85
Oleksyk, T K; Thio, C L; Truelove, A L et al. (2005) Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes Immun 6:347-57
Shrestha, Sadeep; Smith, Michael W; Beaty, Terri H et al. (2005) Theory and methodology for utilizing genes as biomarkers to determine potential biological mixtures. Ann Epidemiol 15:29-38
Smith, Michael W; O'Brien, Stephen J (2005) Mapping by admixture linkage disequilibrium: advances, limitations and guidelines. Nat Rev Genet 6:623-32
Oleksyk, T K; Goldfarb, L G; Sivtseva, T et al. (2004) Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. Eur J Immunogenet 31:121-8

Showing the most recent 10 out of 13 publications