The pathology of mouse models of human cancers and related diseases are studied and characterized using routine and new state-of-the-art pathology techniques including histopathology, immunohistochemistry, ultrastructure, in situ hybridization, image analysis, digital imaging and other methods to detect gene expression. Mouse models include targeted mutants with multiple endocrine disorders, gastrointestinal tumors, lymphomas, leukemias and mammary carcinomas and transgenics with mammary, prostate, and liver carcinomas.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010296-03
Application #
6433234
Study Section
(OLAR)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Boorman, G A; McCormick, D L; Ward, J M et al. (2000) Magnetic fields and mammary cancer in rodents: a critical review and evaluation of published literature. Radiat Res 153:617-26
Qian, X; Esteban, L; Vass, W C et al. (2000) The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J 19:642-54
Ohshima, T; Schiffmann, R; Murray, G J et al. (1999) Aging accentuates and bone marrow transplantation ameliorates metabolic defects in Fabry disease mice. Proc Natl Acad Sci U S A 96:6423-7
Kimura, S; Kawabe, M; Ward, J M et al. (1999) CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. Carcinogenesis 20:1825-30
Peters, J M; Morishima, H; Ward, J M et al. (1999) Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice. Toxicol Sci 50:82-9
Kobayashi, S; Yoshida, K; Ward, J M et al. (1999) Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol 163:4013-9
Kimura, S; Ward, J M; Minoo, P (1999) Thyroid-specific enhancer-binding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia. Biochimie 81:321-7
Morse 3rd, H C; Qi, C F; Tadesse-Heath, L et al. (1999) Novel aspects of murine B cell lymphomas. Curr Top Microbiol Immunol 246:249-55
Ward, J M; Tadesse-Heath, L; Perkins, S N et al. (1999) Splenic marginal zone B-cell and thymic T-cell lymphomas in p53-deficient mice. Lab Invest 79:3-14