Abstract

The variable character of the HIV-1 epidemicamong world populations suggests that racial distribution of polymorphisms for relevantgenes may be important. Polymorphisms in chemokine receptors have been shown to have aprofound effect on both infection and the rate ofprogression to AIDS in Caucasians. Of thethree protective alleles reported, CCR5-delta32,CCR2-64I, andSDF1-3'A, only CCR2-64I iscommon in African-Americans or native Africans,but it appears to be less protective than inCaucasians. We have identified severalpolymorphisms in HIV-1 candidate genes that occurwith high frequency in African-Americans.Preliminary analyses suggest that there may be complex interactions between chemokine receptorgenes that increase susceptibility to diseaseprogression in a cohort of African Americans. Weare also identifying polymorphisms in bothCaucasians and African-Americans that occur inhost genes encoding proteins, includingtranscriptional factors, that are involved inpost-entry events. Several of these polymorphismsare now being screened for their effects oninfection and progression in the two racial groups.Identification of Candidate Gene Polymorphisms that Influence Progression to AIDS

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010297-01
Application #
6101083
Study Section
Special Emphasis Panel (LGD)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

An, Ping; Thio, Chloe L; Kirk, Gregory D et al. (2008) Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. J Infect Dis 198:1159-65
Li, Xing; Gold, Bert; O'hUigin, Colm et al. (2007) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33
Guo, Xiu Chan; Scott, Kevin; Liu, Yan et al. (2006) Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: study design, methods and feasibility. Hum Genomics 2:365-75
Javanbakht, Hassan; An, Ping; Gold, Bert et al. (2006) Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 354:15-27
Modi, William S; Lautenberger, James; An, Ping et al. (2006) Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. Am J Hum Genet 79:120-8
Guo, Xiu-Chan; O'Brien, Stephen J; Winkler, Cheryl et al. (2006) [Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma] Yi Chuan 28:783-90
Walsh, Emily C; Sabeti, Pardis; Hutcheson, Holli B et al. (2006) Searching for signals of evolutionary selection in 168 genes related to immune function. Hum Genet 119:92-102
Song, Byeongwoon; Gold, Bert; O'Huigin, Colm et al. (2005) The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol 79:6111-21
Modi, W S; Scott, K; Goedert, J J et al. (2005) Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes Immun 6:691-8
Duggal, Priya; Winkler, Cheryl A; An, Ping et al. (2005) The effect of RANTES chemokine genetic variants on early HIV-1 plasma RNA among African American injection drug users. J Acquir Immune Defic Syndr 38:584-9

Showing the most recent 10 out of 15 publications