Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010342-07
Application #
7338482
Study Section
Mammalian Cell Lines Committee (MCL)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2006
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Lountos, George T; Austin, Brian P; Nallamsetty, Sreedevi et al. (2009) Atomic resolution structure of the cytoplasmic domain of Yersinia pestis YscU, a regulatory switch involved in type III secretion. Protein Sci 18:467-74
Phan, Jason; Tropea, Joseph E; Waugh, David S (2007) Structure-assisted discovery of Variola major H1 phosphatase inhibitors. Acta Crystallogr D Biol Crystallogr 63:698-704
Phan, Jason; Austin, Brian P; Waugh, David S (2005) Crystal structure of the Yersinia type III secretion protein YscE. Protein Sci 14:2759-63
Schubot, Florian D; Jackson, Michael W; Penrose, Kerri J et al. (2005) Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis. J Mol Biol 346:1147-61
Schubot, Florian D; Cherry, Scott; Austin, Brian P et al. (2005) Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR. Protein Sci 14:1679-83
Lee, Kyeong; Boovanahalli, Shanthaveerappa K; Nam, Ky-Youb et al. (2005) Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett 15:4037-42
Swietnicki, Wieslaw; O'Brien, Sarah; Holman, Kari et al. (2004) Novel protein-protein interactions of the Yersinia pestis type III secretion system elucidated with a matrix analysis by surface plasmon resonance and mass spectrometry. J Biol Chem 279:38693-700
Schubot, Florian D; Waugh, David S (2004) A pivotal role for reductive methylation in the de novo crystallization of a ternary complex composed of Yersinia pestis virulence factors YopN, SycN and YscB. Acta Crystallogr D Biol Crystallogr 60:1981-6
Derewenda, Urszula; Mateja, Agnieszka; Devedjiev, Yancho et al. (2004) The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague. Structure 12:301-6
Phan, Jason; Lee, Kyeong; Cherry, Scott et al. (2003) High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide. Biochemistry 42:13113-21

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