In this study, pegylated interferon alfa-2b (PEG-Intron) is administerd subcutaneously once a week to pediatric patients with diffuse pontine gliomas who have completed radiation therapy. The endpoint of the trial is 2-year survival compared to historical controls. To date, 17 patients have been enrolled. All patients have tolerated the PEG-Introntherapy well, with no adverse events directly attributable to the study agent. The study is enrolling 24 patients and taking an early look for efficacy. Two of our patients to date have survived 2 years from diagnosis. The study is ongoing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010580-04
Application #
7592775
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2007
Total Cost
$164,437
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Steffen-Smith, Emilie A; Venzon, David J; Bent, Robyn S et al. (2012) Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma. Int J Radiat Oncol Biol Phys 84:774-9
Hayward, Robert M; Patronas, Nicolas; Baker, Eva H et al. (2008) Inter-observer variability in the measurement of diffuse intrinsic pontine gliomas. J Neurooncol 90:57-61