The long-standing focus of the laboratory program involves the radiation- and microenvironmental stress response. We have studied the effects of tumor hypoxia and are now investigating the role of HIF 1 and 2 in radiation sensitization. A somewhat related set of studies involves the role of NSAID and COX inhibitors as radiation modifiers.A new program is entitled, """"""""Radiation-inducible molecular targets"""""""" that is exploring the use of fractionated radiation to induce a cellular phenotype that makes the cell susceptible for molecular-targeted therapy. In essence, radiation would set up the tumor for enhanced drug killing. This work is in its early stages. Clinical interests include prostate cancer and the lymphomas.
Tsai, Mong-Hsun; Cook, John A; Chandramouli, Gadisetti V R et al. (2007) Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation. Cancer Res 67:3845-52 |