Abstract

The Histology Laboratory of the Laboratory of Pathology (LOP) is a core facility devoted to supporting the clinical activities of LOP. This consists of accessioning human tissues removed at surgery or in clinics, processing the tissues, preparing and staining slides for microscopy. Within the LOP, the Histology lab serves the Surgical Pathology, Hematopathology, Postmortem Pathology, Cytopathology, and Ultrastructural and Pediatric Pathology sections as well as the Specialized Diagnostics Unit. During FY06, about 15,000 tissue blocks were prepared from over 6,000 specimens and over 97,000 slides were cut and stained. Additionally, the laboratory processes case material sent in consultation or for review prior to protocol entry for patients in the Clinical Center. This fiscal year over 50,000 consult slides over 3500 cases were received. Although about 95% of effort is devoted to clinical duties, the Histology Laboratory also performs recuts of tissue blocks and does some routine staining for research projects in NCI by arrangement. This activity is coordinated with the tissue research request function of Clinical Operations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010687-03
Application #
7592856
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2007
Total Cost
$1,171,784
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Osinusi, Anu; Kleiner, David; Wood, Brad et al. (2009) Rapid development of advanced liver fibrosis after acquisition of hepatitis C infection during primary HIV infection. AIDS Patient Care STDS 23:403-6
Perumalswami, Ponni; Kleiner, David E; Lutchman, Glen et al. (2006) Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection. Hepatology 43:780-7
De Ravin, Suk See; Naumann, Nora; Robinson, Michael R et al. (2006) Sarcoidosis in chronic granulomatous disease. Pediatrics 117:e590-5
Lutchman, Glen; Promrat, Kittichai; Kleiner, David E et al. (2006) Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement. Clin Gastroenterol Hepatol 4:1048-52
O'Brien, Kevin; Hussain, Nadeem; Warady, Bradley A et al. (2006) Nodular regenerative hyperplasia and severe portal hypertension in cystinosis. Clin Gastroenterol Hepatol 4:387-94
Conjeevaram, Hari S; Fried, Michael W; Jeffers, Lennox J et al. (2006) Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology 131:470-7
Beck, Kimberly E; Blansfield, Joseph A; Tran, Khoi Q et al. (2006) Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 24:2283-9
Greenberg, David E; Ding, Li; Zelazny, Adrian M et al. (2006) A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease. PLoS Pathog 2:e28
Maker, Ajay V; Phan, Giao Q; Attia, Peter et al. (2005) Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 12:1005-16
Javor, Edward D; Ghany, Marc G; Cochran, Elaine K et al. (2005) Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 41:753-60

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