This is a collaborative research program being performed with Dr. David Mann of the American Red Cross, Rockville, Maryland as part of a scientific program investigating the structure and function of the novel antimicrobial domain of the iron-binding host defense protein, lactoferrin (LF). Our specific efforts are directed towards an assessment of the microbiological effects of a LF peptide, in particular, its defensin-like properties as they pertain to mycobacteria.
The aims are to: (1) measure the bactericidal effects of the LF-defensin on various specias of mycobacteria; (2) to investigate the synergistic bacteriocidal effect of LF-defensin and anti-mycobacterial drugs on mycobacteria and; (3) to develop strategies for delivering defensins, as potentiators of anti-mycobacterial drugs and for the effective killing of mycobacteria residing within host cells.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BJ006014-02
Application #
6161224
Study Section
Special Emphasis Panel (LM)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost