The current tuberculosis vaccine, BCG, has questionable efficacy and undoubtedly new vaccines are needed. Recent studies have indicated that DNA vaccines may be promising as new mycobacterial vaccines candidates. We are currently generating DNA vectors encoding these different mycobacterial antigens (ESAT6, KatG, and HBHA) for testing in animal models of tuberculosis. We are also developing cytokine assays to investigate whether cytokine responses are potential surrogates of DNA vaccine effectiveness.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BJ006015-01
Application #
2456625
Study Section
Special Emphasis Panel (LM)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost