Abstract

Each lot of OPV is tested for neurovirulence by intraspinal inoculation of monkeys. We have investigated the possibility of replacing monkeys with poliovirus-susceptible transgenic mice. LMD has led and coordinated a collaborative WHO study of this topic, phase 2 of which has been completed in 1997. Progress in the second phase is described above.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BR005003-07
Application #
6161396
Study Section
Special Emphasis Panel (LMD)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost