The treatment and pathophysiology of various renal disorders will be better understood if the GFR and RBF are measured. Problems with simple serum creatinine and 24-hour urine collections have led to the desire for a more precise method for their calculation. Different groups of patients currently are being treated here with Cyclosporine for Multiple Sclerosis, Membranous Lupus Nephritis, and Uveitis. The dosage of their Cyclosporine will be altered based on their GFR and ERPF and clinical condition. The studies are performed in the Nuclear Medicine Department following the injection and equilibration of the radiotracers. Timed blood and urine specimens are obtained and then counted to calculate the GFR and ERPF.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL001005-04
Application #
3896264
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code