Abstract

In 2002 we reported the occurence of avascular necrosis of bone (usually the hip) in 15 asymptomatic patients with HIV disease. We are currently assessing the natural history of avascular necrosis in this chart and in an additional ten patients with symptomatic disease. The occurence of pain and functional disability is being assessed. The development of AVN at other sites is also being evaluated by yearly MRIs. The study will elucidate natural history and risk factors for this unexpected complication of treated HIV disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL001159-04
Application #
6683785
Study Section
(CCM)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Morse, Caryn G; Kovacs, Joseph A (2006) Metabolic and skeletal complications of HIV infection: the price of success. JAMA 296:844-54
Miller, Kirk D; Masur, Henry; Jones, Elizabeth C et al. (2002) High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med 137:17-25
Miller, K D; Spooner, K; Herpin, B R et al. (2001) Immunotherapy of HIV-infected patients with intermittent interleukin-2: effects of cycle frequency and cycle duration on degree of CD4(+) T-lymphocyte expansion. Clin Immunol 99:30-42