p11 is a protein which can bind to and inhibit cytosolic Phospholipase A2. Modulation of p11 levels might provide a way to control a variety of cellular functions. Control of p11 has been studied at the protein and mRNA level. The p11 5' promoter has been cloned, sequenced, and characterized. p11 protein production has been studied in response to dexamethasone and to retonoic acid. The effect of cytokine and growth factor stimulation of epithelial cells on p11 production is also being studied. p11 gene expression is enhanced by stimulation with epidermal growth factor or with interferon gamma. Two manuscripts have been published and two are in preparation.
| Huang, Xiuli; Pawliczak, Rafal; Yao, Xiang-Lan et al. (2003) Characterization of the human p11 promoter sequence. Gene 310:133-42 |
| Huang, Xiu-li; Pawliczak, Rafal; Yao, Xiang-lan et al. (2003) Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter. J Biol Chem 278:9298-308 |
| Huang, Xiu-Li; Pawliczak, Rafal; Cowan, Mark J et al. (2002) Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells. J Biol Chem 277:38431-40 |
| Pawliczak, R; Cowan, M J; Huang, X et al. (2001) p11 expression in human bronchial epithelial cells is increased by nitric oxide in a cGMP-dependent pathway involving protein kinase G activation. J Biol Chem 276:44613-21 |
