Preclinical investigation has shown the role for endogenous opioid system in the regulation of eating. Naloxone, an antagonist, has been shown to reduce eating and food consumption. This study was designed to attempt to correlate plasma in anorexic, bulemia, and control subjects. We have been able to measure naloxone concentration in 5 subjects using a sensitive HPLC method that employs electrochemical detection. We are in the process of collating data before performing correlation analysis.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL005053-01
Application #
4691989
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code