Fentanyl is a commonly used narcotic that has wide applications in general anesthesia and critical care settings. We have previously shown that fentanyl, an opioid agonist, when administered to canines: (1) blocked b-adrenergic hemodynamic responses to epinephrine and isoproterenol;(2) did not effect the a-adrenergic effects of epinephrine or phenylephrine. These studies were extended to define the mechanism of fentanyl-catecholamine interactions by performing similar studies in canines with a vagotomy. These studies have implications for understanding the mechanism that accounts for altered hemodynamic responses due to fentanyl in anesthesia and in critically ill patients.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL008046-01
Application #
6548784
Study Section
Anesthesiology Training Committee (ANES)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
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