This project has explored approaches, methods, and concepts for assessing the clinical performance of laboratory tests. Focus has been on basic discrimination accuracy as reflected in clinical sensitivity and specificity and as represented by receiver operating characteristic (ROC) plots. ROC plotting and analysis has been applied to patient databases, especially involving the use if lipid and apolipoprotein parameters to identify subjects with clinically important coronary artery disease (CAD). Two such studies revealed that all of these parameters have only modest ability to discriminate between subjects with and without CAD. A tentative guideline for use by the clinical laboratory community in assessing clinical accuracy of tests has been developed and published through the National Committee for Clinical Laboratory Standards.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010153-09
Application #
5201172
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code