Under certain circumstances heparin stimulates platelets and may cause thrombocytopenia. This laboratory has analyzed the initial step in this process, the binding of heparin to the cells. It has been shown that this binding is saturable and reversible. The binding constants are a function of heparin molecular weight and the state of platelet activation. Activated platelets compete with secreted heparin-binding protein (e.g., platelet factor 4) for heparin.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010192-03
Application #
3837998
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code