Abstract

Monocytes are being characterized for the expression levels of CD40, CD80, CD86, CD120b, and the gamma interferon receptor alpha chain. These studies have identified 2 patients with gamma interferon receptor alpha chain deficiency, and the molecular level of this defect is being actively examined. There are emerging data that CD120b expression may also be abnormal in some patients with recurrent mycobacterial infection. Specific expression of the gamma interferon receptor alpha chain is being evaluated on amniocytes as a possible approach to prenatal diagnosis of this disorder.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010286-01
Application #
6161567
Study Section
Cognition and Perception Study Section (CP)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Bleesing, J J; Fleisher, T A (2001) Cell function-based flow cytometry. Semin Hematol 38:169-78
Uzel, G; Frucht, D M; Fleisher, T A et al. (2001) Detection of intracellular phosphorylated STAT-4 by flow cytometry. Clin Immunol 100:270-6
Fleisher, T A; Dorman, S E; Anderson, J A et al. (1999) Detection of intracellular phosphorylated STAT-1 by flow cytometry. Clin Immunol 90:425-30