We will analyze CT colonography (virtual colonoscopy) data using computer-assisted diagnosis methods. These methods attempt to identify and characterize colonic polyps automatically, thereby improving physician accuracy and efficiency. We will compare the results of the computer analyses with the ground truth data (conventional colonoscopy, pathologic analysis). We made a number of advances over the past year, including advances in colon and polyp segmentation, feature extraction methods, false positive reduction and classifier optimization. We just had accepted for publication a major trial of computer-aided polyp detection (Gastroenterology, accepted for publication). This trial showed that computer-aided polyp detection is robust, reproducible and accurate for polyps 8 mm and larger. We also made a clinical observation that oral contrast sticks to some polyps, especially those with villous histology. This finding has implications for radiologic interpretation.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL040003-03
Application #
7215865
Study Section
(DRD)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2005
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Summers, Ronald M; Liu, Jiamin; Sussman, Daniel L et al. (2012) Association between visceral adiposity and colorectal polyps on CT colonography. AJR Am J Roentgenol 199:48-57
Roney, Celeste A; Xu, Biying; Xie, Jianwu et al. (2011) Rh-I-UEA-1 polymerized liposomes target and image adenomatous polyps in the APC(Min/+) mouse using optical colonography. Mol Imaging 10:305-16
Summers, Ronald M (2010) Polyp size measurement at CT colonography: what do we know and what do we need to know? Radiology 255:707-20
Huang, Adam; Li, Jiang; Summers, Ronald M et al. (2010) Improving Polyp Detection Algorithms for CT Colonography: Pareto Front Approach. Pattern Recognit Lett 31:1461-1469
Summers, Ronald M; Frentz, Suzanne M; Liu, Jiamin et al. (2009) Conspicuity of colorectal polyps at CT colonography: visual assessment, CAD performance, and the important role of polyp height. Acad Radiol 16:4-14
Petrick, Nicholas; Haider, Maruf; Summers, Ronald M et al. (2008) CT colonography with computer-aided detection as a second reader: observer performance study. Radiology 246:148-56
Wang, Shijun; Yao, Jianhua; Summers, Ronald M (2008) Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction. Med Phys 35:1377-86
Summers, Ronald M; Handwerker, Laurie R; Pickhardt, Perry J et al. (2008) Performance of a previously validated CT colonography computer-aided detection system in a new patient population. AJR Am J Roentgenol 191:168-74
Li, Jiang; Van Uitert, Robert; Yao, Jianhua et al. (2008) Wavelet method for CT colonography computer-aided polyp detection. Med Phys 35:3527-38
Van Uitert, Robert L; Summers, Ronald M; White, Jacob M et al. (2008) Temporal and multiinstitutional quality assessment of CT colonography. AJR Am J Roentgenol 191:1503-8

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