Abstract

The purpose of this protocol is to develop novel methods of performing magnetic resonance imaging (MRI) evaluations so that these methods can be transferred to the clinical environment. Normal volunteers are recruited to optimize imaging techniques and the protocol has been very successful in recruiting normal volunteers. Among the accomplishments of this protocol over the last year include optimizing imaging on the new 3T MRI unit, developing new methods of performing MR angiograms of the runoff vessels of the lower extremity, improving the performance of prostate MRI particularly in improving MR spectroscopy, motion tracking for knee and patella movement, functional MRI of the brain, evaluating oxygenation in the brain, and stroke protocols. We have made substantial gains in technical development in all of these areas and there have been no complications. This protocol therefore provides an invaluable resource to the NIH by allowing optimization of MRI in normal volunteers in order to apply these improvements to clinical patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL040009-05
Application #
6844458
Study Section
(DRD)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Yim, Peter J; Cebral, Juan R; Weaver, Ashley et al. (2004) Estimation of the differential pressure at renal artery stenoses. Magn Reson Med 51:969-77
Ho, Vincent B; Corse, William R (2003) MR angiography of the abdominal aorta and peripheral vessels. Radiol Clin North Am 41:115-44
Leiner, Tim; Ho, Kai Yiu J A M; Ho, Vincent B et al. (2003) Multicenter phase-II trial of safety and efficacy of NC100150 for steady-state contrast-enhanced peripheral magnetic resonance angiography. Eur Radiol 13:1620-7
Marcos, Hani B; Zhang, Yantian; Choyke, Peter L (2003) Functional studies of the kidney with magnetic resonance imaging. Methods Mol Med 86:69-77
Choyke, Peter L; Dwyer, Andrew J; Knopp, Michael V (2003) Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 17:509-20
Yim, Peter J; Vasbinder, G Boudewijn C; Ho, Vincent B et al. (2003) Isosurfaces as deformable models for magnetic resonance angiography. IEEE Trans Med Imaging 22:875-81
Ho, Vincent B; Corse, William R; Hood, Maureen N et al. (2003) MRA of the thoracic vessels. Semin Ultrasound CT MR 24:192-216