We have been studying gene expression in cytotoxic immune cells with specific emphasis on large granular lymphocytes (LGLs) and cytotoxic T cells. We have been characterizing a new gene which appears to be a receptor for LGLs and is expressed in the cytoplasm of T cells. We have also correlated cytotoxic function with expression of the cytotoxic protein, perforin, and have identified cytokines which upregulate perforin mRNA expression. These studies begin to define, at the molecular level, the genes involved in the development and maturation of cytotoxic immune effector cells.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CM009345-02
Application #
3853325
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Division of Cancer Treatment
Department
Type
DUNS #
City
State
Country
United States
Zip Code