Abstract

to determine whether a low fat, high fiber, high vegetable and fruit eating plan will decrease the recurrence of adenomatous polyps of the large bowel.BACKGROUND: In the PPT, three dietary factors are being investigated simultaneously through intervention with a realistic, comprehensive dietary pattern change. Large bowel adenomas present a unique opportunity to conduct an intervention trial because of the high prevalence of these lesions, the high recurrence rate, and the fact that adenomas are considered precursors for most large bowel cancers. METHODS: Men and women with one or more adenomas recently removed were randomized at eight Clinical Centers between June 1991 and January 1994. The goals for the intervention group are 20% of calories from fat, 18g fiber/1000 kcal, and 5-8 servings of fruits and vegetables (the exact number based on caloric intake). The intervention program integrates nutrition education and behavior modification techniques. Participants in the control group are expected to maintain their usual diet. The PPT found no effect of the intervention diet on the recurrence of colorectal adenomatous polyps. Particpants from this trial have been recrutied into the PPT Continued Follow-up Study. We are collecting data on polyp recurrence and diet. Participants will be followed until April 2004.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Prevention And Control (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CN000151-15
Application #
6952218
Study Section
(BBRL)
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Cancer Prevention and Control
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Brown, David A; Hance, Kenneth W; Rogers, Connie J et al. (2012) Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15): a potential screening tool for the prevention of colon cancer? Cancer Epidemiol Biomarkers Prev 21:337-46
Murphy, Gwen; Cross, Amanda J; Sansbury, Leah S et al. (2009) Dopamine D2 receptor polymorphisms and adenoma recurrence in the Polyp Prevention Trial. Int J Cancer 124:2148-51
Lanza, Elaine; Yu, Binbing; Murphy, Gwen et al. (2007) The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization. Cancer Epidemiol Biomarkers Prev 16:1745-52
Wanke, Kay L; Daston, Cassandra; Slonim, Amy et al. (2007) Adherence to the polyp prevention trial dietary intervention is associated with a behavioral pattern of adherence to nondietary trial requirements and general health recommendations. J Nutr 137:391-8
Jacobs, Elizabeth T; Lanza, Elaine; Alberts, David S et al. (2006) Fiber, sex, and colorectal adenoma: results of a pooled analysis. Am J Clin Nutr 83:343-9
Lanza, Elaine; Hartman, Terryl J; Albert, Paul S et al. (2006) High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial. J Nutr 136:1896-903
Sansbury, Leah B; Bergen, Andrew W; Wanke, Kay L et al. (2006) Inflammatory cytokine gene polymorphisms, nonsteroidal anti-inflammatory drug use, and risk of adenoma polyp recurrence in the polyp prevention trial. Cancer Epidemiol Biomarkers Prev 15:494-501
Hartman, Terryl J; Albert, Paul S; Snyder, Kirk et al. (2005) The association of calcium and vitamin D with risk of colorectal adenomas. J Nutr 135:252-9
Woodson, Karen; Weisenberger, Daniel J; Campan, Mihaela et al. (2005) Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. Cancer Epidemiol Biomarkers Prev 14:1219-23
Pabby, Ajay; Schoen, Robert E; Weissfeld, Joel L et al. (2005) Analysis of colorectal cancer occurrence during surveillance colonoscopy in the dietary Polyp Prevention Trial. Gastrointest Endosc 61:385-91

Showing the most recent 10 out of 17 publications