This long-term project continues to evaluate the potential carcinogenic effects of a multitude of substances in nonhuman primates. These include nitroso-compounds, antineoplastic and immunosuppressive agents, 'classical' rodent carcinogens, food additives, food components, and environmental contaminants. The most recent compounds introduced into the colony include the heterocyclic amines, 2-amino-3-methyl-3H-imidazo[4,5A]quinoline (IQ), 2-amino-3,8-dimethyl [4,5-f] quinoxaline (MeIQx) and 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) which are potent mutagens found in cooked meat. Of a group of 20 monkeys which have received 20 mg/kg of IQ since 1985 nine are dead with primary hepatocellular carcinoma (HCC) and two are alive with HCC. Two of the monkeys receiving 10 mg/kg of IQ have died with HCC, and two are alive with HCC. DNA IQ-adducts have been found in peripheral blood cells in a number of the IQ monkeys. The MeIQx which was started 1/2 years ago has no yet revealed any liver abnormalities, and no DNA-adduct levels were found in peripheral blood cells. Monkeys sacrificed after nine doses of PhIP administration were shown to have high DNA-adduct levels in the heart and liver. Twenty monkeys have been assigned to chronic PhIP administration (20 mg/kg), three of which have already started. Concerning the other compounds used in the program the most interesting finding was a metastatic HCC diagnosed in a monkey which had received DDT for 19 years.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP003509-27
Application #
3874587
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code