Studies of Persons at High Risk of Cancer

Tucker, M A.

Abstract

The studies of melanoma-prone families, families with multiple endocrine neoplasia type 1, and nevoid basal cell carcinoma syndrome have continued. Case-control studies of lung cancer and bladder cancer with biochemical components have continued, and a case-control study of melanoma was initiated. Lung cancer risk is greatest in extensive metabolizers of debrisoquine. A new study of the risk of second cancers after ovarian cancer was started, and the analysis of second cancers after childhood cancer revealed a risk of thyroid cancer related to treatment with radiation. Analysis of the CASH data revealed that among blacks, the genetic model which fits the data most closely is autosomal recessive. Among whites, the segregation pattern differs by histologic type of breast cancer.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Intramural Research (Z01)
• Project #: 1Z01CP004410-14
• Application #: 3874594
• Support Year: 14
• Fiscal Year: 1990

Institution

• Name: Division of Cancer Epidemiology and Genetics
• Country: United States

Publications

Goldin, Lynn R; McMaster, Mary L; Caporaso, Neil E (2013) Precursors to lymphoproliferative malignancies. Cancer Epidemiol Biomarkers Prev 22:533-9

Han, Summer S; Yeager, Meredith; Moore, Lee E et al. (2012) The chromosome 2p21 region harbors a complex genetic architecture for association with risk for renal cell carcinoma. Hum Mol Genet 21:1190-200

Brau-Javier, Cristina N; Gonzales-Chavez, Jose; Toro, Jorge R (2012) Chronic cutaneous pustulosis due to a 175-kb deletion on chromosome 2q13: excellent response to anakinra. Arch Dermatol 148:301-4

Kristinsson, Sigurdur Y; Goldin, Lynn R; Turesson, Ingemar et al. (2012) Familial aggregation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with solid tumors and myeloid malignancies. Acta Haematol 127:173-7

Goldin, Lynn R; Kristinsson, Sigurdur Y; Liang, Xueying Sharon et al. (2012) Familial aggregation of acute myeloid leukemia and myelodysplastic syndromes. J Clin Oncol 30:179-83

Lindqvist, Ebba K; Goldin, Lynn R; Landgren, Ola et al. (2011) Personal and family history of immune-related conditions increase the risk of plasma cell disorders: a population-based study. Blood 118:6284-91

Goldin, Lynn R; Lanasa, Mark C; Slager, Susan L et al. (2010) Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol 151:152-8

Kristinsson, Sigurdur Y; Björkholm, Magnus; Goldin, Lynn R et al. (2009) Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden. Int J Cancer 125:2147-50

Bradford, Porcia T; Goldstein, Alisa M; McMaster, Mary L et al. (2009) Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol 145:427-34

Kristinsson, Sigurdur Y; Koshiol, Jill; Goldin, Lynn R et al. (2009) Genetics- and immune-related factors in the pathogenesis of lymphoplasmacytic lymphoma/ Waldenström's macroglobulinemia. Clin Lymphoma Myeloma 9:23-6