Human herpesvirus 8 (HHV-8): An immunofluorescence assay for latent HHV-8 antibodies revealed that U.S. homosexual men experienced an HHV-8 epidemic concurrent with the HIV epidemic in the early 1980s. HHV-8 infection was associated with numerous homosexual partners, and 35% of subjects with both HHV-8 and HIV developed Kaposi's sarcoma within 10 years. Five prototype assays for detection of HHV-8 antibodies were evaluated, and a combination of two (immunofluorescence for latent nuclear antibodies and enzyme immunoassay for antibodies against K8.1 recombinant protein) had particularly high sensitivity and specificity. Polyomaviruses: A study to examine reproducibility in detection of SV40 DNA in human mesothelioma or normal lung in nine laboratories was initiated. Hepatitis Viruses: Among subjects in the Multicenter Hemophilia Cohort Study, low levels of heterosexual transmission from men with hemophilia to their wives with hepatitis C virus (HCV) and hepatitis G virus (HGV). With HCV/HIV co-infection, atypical HCV antibody patterns were associated with an increased risk of end-stage liver disease. With HGV/HIV co-infection, AIDS risk was reduced 40% compared to HIV infection without HGV. In a case-control study in the Gambia of hepatocellular carcinoma associated with hepatitis B virus (HBV) and aflatoxin exposure, a technique was developed to detect the pathognomonic ser249 mutation of the p53 gene in plasma.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP005782-06
Application #
6433270
Study Section
(VEB)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Bekker, Vincent; O'Brien, Thomas R; Chanock, Stephen (2009) Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry. Hum Hered 67:206-16
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Ioannidis, John P A; Boffetta, Paolo; Little, Julian et al. (2008) Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 37:120-32
O'Brien, Thomas R; Kachapati, Kritika; Zhang, Mingdong et al. (2007) HCV infection clearance with functional or non-functional caspase-12. Scand J Gastroenterol 42:416-7
Kachapati, Kritika; O'Brien, Thomas R; Bergeron, Julie et al. (2006) Population distribution of the functional caspase-12 allele. Hum Mutat 27:975
Blattner, William A; Oursler, Kris Ann; Cleghorn, Farley et al. (2004) Rapid clearance of virus after acute HIV-1 infection: correlates of risk of AIDS. J Infect Dis 189:1793-801
Tanaka, Yasuhito; Pfeiffer, Ruth; Yeo, Anthony E T et al. (2004) PCR-probe capture hybridization assay and statistical model for SEN virus prevalence estimation. J Med Virol 73:123-30
Maloney, E M; Hisada, M; Palmer, P et al. (2000) Human T cell lymphotropic virus type I-associated infective dermatitis in Jamaica: a case report of clinical and biologic correlates. Pediatr Infect Dis J 19:560-5
Hayes, R B; Pottern, L M; Strickler, H et al. (2000) Sexual behaviour, STDs and risks for prostate cancer. Br J Cancer 82:718-25
Hisada, M; Rabkin, C S; Strickler, H D et al. (2000) Human papillomavirus antibody and risk of prostate cancer. JAMA 283:340-1

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