Many of the investigations in this genetic epidemiology project arise from observations in families at high risk of cancer or in other etiologic studies. Analyses of the data from the survey of the Jewish population in the metropolitan D.C. area continued. Risks of second cancers following breast cancer were assessed. The risk of contralateral breast cancer was not significantly higher among mutation carriers compared to noncarriers. Risk of a second ovary cancer, however, was higher. Retrospective review of cranial CT studies in 56 patients with medulloblastoma and 159 emergency room controls revealed that 9% of medulloblastoma patients without shunts, 16% with shunts, and 10% of emergency room controls had falx calcification. Only the two patients with both medulloblastoma and the nevoid basal cell carcinoma syndrome, however, demonstrated falx calcification in the peridiagnostic period. Among individuals with Beckwith-Wiedemann syndrome, approximately 25% have nonmalignant renal abnormalities including medullary renal cysts, caliceal diverticula, hydronephrosis and nephrolithiasis. As a follow-up to a just completed DCEG comprehensive case-control study of adults with brain tumors, a family-based study of the parents, siblings and adult children of the 480 eligible glioma cases is being conducted. Relatives will be interviewed about personal and family medical history and other risk factors and will be asked to provide buccal cells as a source of DNA. The relatives will be used as controls for the glioma cases in association studies and in analyses to evaluate the roles of genetic susceptibility and environmental exposures on the risk of gliomas and etiologically related tumors. Epidemiologic and genetic approaches for examining gene-environment interaction were reviewed. Traditional epidemiologic approaches have sufficient power to detect interaction in studies of common genetic and/or environmental factors. Studies of rare factors, however, will likely require alternative study designs such as multi-stage sampling, countermatching or case-case designs. - Human Subjects & Human Subjects: Minor under 18 Years Old & Human Subjects: Interview, Questionaires, or Surveys Only

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP005803-05
Application #
6289525
Study Section
Special Emphasis Panel (GEB)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Goldin, Lynn R; Bjorkholm, Magnus; Kristinsson, Sigurdur Y et al. (2009) Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica 94:647-53
Goldin, Lynn; Bjorkholm, Magnus; Kristinsson, Sigurdur et al. (2009) Germline and somatic JAK2 mutations and susceptibility to chronic myeloproliferative neoplasms. Genome Med 1:55
Landgren, Ola; Pfeiffer, Ruth M; Stewart, Laveta et al. (2007) Risk of second malignant neoplasms among lymphoma patients with a family history of cancer. Int J Cancer 120:1099-102
Yang, Xiaohong R; Sherman, Mark E; Rimm, David L et al. (2007) Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 16:439-43
R Yang, X; Pfeiffer, R M; Goldstein, A M (2006) Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. J Med Genet 43:e16
Landgren, Ola; Linet, Martha S; McMaster, Mary L et al. (2006) Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: a population-based case-control study. Int J Cancer 118:3095-8
Landgren, Ola; Engels, Eric A; Caporaso, Neil E et al. (2006) Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries. Blood 108:292-6
Yang, Xiaohong Rose; Charette, Lori A; Garcia-Closas, Montserrat et al. (2006) Construction and validation of tissue microarrays of ductal carcinoma in situ and terminal duct lobular units associated with invasive breast carcinoma. Diagn Mol Pathol 15:157-61
Goldstein, Alisa M; Dondon, Marie-Gabrielle; Andrieu, Nadine (2006) Unconditional analyses can increase efficiency in assessing gene-environment interaction of the case-combined-control design. Int J Epidemiol 35:1067-73
Landi, Maria Teresa; Kanetsky, Peter A; Tsang, Shirley et al. (2005) MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population. J Natl Cancer Inst 97:998-1007

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