Assessment of occupational exposures is a crucial factor in evaluating dose-response relationships and most studies conducted by the Section have an extensive exposure assessment component. Major assessment efforts in cohort studies have involved exposures to acrylonitrile, organic solvents, pesticides, formaldehyde, benzene, xylene, toluene and diesel fumes. In the case-control design, jobs have been evaluated for a wide variety of exposures, including chlorinated hydrocarbons and other solvents, dusts, asbestos, formaldehyde, electromagnetic fields, physical activity, nitrosamines, polycyclic aromatic hydrocarbons, pesticides and cadmium. These exposures have been evaluated in studies of cancer of the peritoneum, breast, kidney, colon, stomach, nasopharynx, esophagus, pancreas, prostate, brain, and lymphatic and hematopoietic system and for studies of parental occupation and childhood cancers. Sixty-three job-specific questionnaires have been developed for a new case-control study of bladder cancer that allow collection of detailed information on specific jobs. Methodologic studies are also conducted to improve exposure assessment techniques and to understand exposure patterns. Job exposure matrices (JEM) assigning a level, probability and exposure profiles have been developed for several occupational exposures. Differences of level of formaldehyde exposure between whites and African Americans were examined.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010122-02
Application #
6161647
Study Section
Special Emphasis Panel (OEB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Friesen, Melissa C; Bassig, Bryan A; Vermeulen, Roel et al. (2017) Evaluating Exposure-Response Associations for Non-Hodgkin Lymphoma with Varying Methods of Assigning Cumulative Benzene Exposure in the Shanghai Women's Health Study. Ann Work Expo Health 61:56-66
Locke, Sarah J; Deziel, Nicole C; Koh, Dong-Hee et al. (2017) Evaluating predictors of lead exposure for activities disturbing materials painted with or containing lead using historic published data from U.S. workplaces. Am J Ind Med 60:189-197
Friesen, Melissa C; Shortreed, Susan M; Wheeler, David C et al. (2015) Using hierarchical cluster models to systematically identify groups of jobs with similar occupational questionnaire response patterns to assist rule-based expert exposure assessment in population-based studies. Ann Occup Hyg 59:455-66
Friesen, Melissa C; Locke, Sarah J; Chen, Yu-Cheng et al. (2015) Historical occupational trichloroethylene air concentrations based on inspection measurements from shanghai, china. Ann Occup Hyg 59:62-78
Park, D U; Friesen, M C; Roh, H S et al. (2015) Estimating retrospective exposure of household humidifier disinfectants. Indoor Air 25:631-40
DellaValle, Curt T; Purdue, Mark P; Ward, Mary H et al. (2015) Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure. Ann Occup Hyg 59:609-15
Koh, Dong-Hee; Locke, Sarah J; Chen, Yu-Cheng et al. (2015) Lead exposure in US worksites: A literature review and development of an occupational lead exposure database from the published literature. Am J Ind Med 58:605-16
Wheeler, David C; Archer, Kellie J; Burstyn, Igor et al. (2015) Comparison of ordinal and nominal classification trees to predict ordinal expert-based occupational exposure estimates in a case-control study. Ann Occup Hyg 59:324-35
Friesen, Melissa C; Locke, Sarah J; Tornow, Carina et al. (2014) Systematically extracting metal- and solvent-related occupational information from free-text responses to lifetime occupational history questionnaires. Ann Occup Hyg 58:612-24
Koh, Dong-Hee; Nam, Jun-Mo; Graubard, Barry I et al. (2014) Evaluating temporal trends from occupational lead exposure data reported in the published literature using meta-regression. Ann Occup Hyg 58:1111-25

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