This project involves the development of assays for a comprehensive set of SNPs in genes involved in repairing damaged DNA. They will be used to evaluate these genes as cancer susceptibility factors in epidemiologic studies. In addition, we are comparing functional DNA repair assays with genotype information.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP010157-02
Application #
6755613
Study Section
(HGP)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Stredrick, Denise L; Garcia-Closas, Montserrat; Pineda, Marbin A et al. (2006) The ATM missense mutation p.Ser49Cys (c.146C>G) and the risk of breast cancer. Hum Mutat 27:538-44
Sigurdson, Alice J; Hauptmann, Michael; Alexander, Bruce H et al. (2005) DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals. Mutat Res 586:173-88
Sigurdson, Alice J; Hauptmann, Michael; Chatterjee, Nilanjan et al. (2004) Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. BMC Cancer 4:9
Mateus Pereira, Lutecia H; Sigurdson, Alice J; Doody, Michele M et al. (2004) CHEK2:1100delC and female breast cancer in the United States. Int J Cancer 112:541-3