We have previously identified that PGP9.5 is frequently overexpressed in lung cancers. We have also used yeast two-hybrid assay to identify genes that interact with PGP9.5. We recently showed that three genes, JAB1, UBC9 and RanBPM, are associated with PGP9.5 both in vitro and in vivo. Site-directed mutagenesis method is being used to determine the regions of PGP9.5 protein that interact with these factors. We are also also in the process of developing a mouse model that allows for tissue specific expression of PGP.5 in the small airway of the lung to determine the role of PGP9.5 in lung tumorigenesis.
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| He, Ping; Varticovski, Lyuba; Bowman, Elise D et al. (2004) Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Hum Pathol 35:1196-209 |
| Monitto, Constance L; Dong, Seung-Myung; Jen, Jin et al. (2004) Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia. Clin Cancer Res 10:5862-9 |
| Krop, Ian; Player, Audrey; Tablante, Ana et al. (2004) Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res 2:489-94 |
| Player, Audrey; Gillespie, John; Fujii, Takeshi et al. (2003) Identification of TDE2 gene and its expression in non-small cell lung cancer. Int J Cancer 107:238-43 |
