Hearing loss loci segregating in consanguineous families from India and Pakistan were ascertained. Each family consisted of at least four affected children related to each other through a consanguineous union. Some of these families mapped to known loci such as DFNB3, DFNB4, DFNB6, DFNB8/DFNB10 and DFNB12. Others represent mutations in new DFNB genes that are being mapped such as DFNB18. A large number of additional consanguineous Indian families with nonsyndromic hereditary hearing impairment have recently been ascertained which support LOD scores over 3. DNA samples from these families are being analyzed for localization to known loci. Any families unlinked to the known DFNB and DFNA loci will then be mapped to find additional locations for recessive loci causing nonsyndromic hereditary hearing impairment. - recessive deafness, genetic mapping, cloning, unconventional myosins, MYO15, DFNA and DFNB loci - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Intramural Research (Z01)
Project #
1Z01DC000035-03
Application #
6289641
Study Section
Special Emphasis Panel (LMG)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
National Institute on Deafness and Other Communication Disorders
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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