The principle objective of this project is to systematically screen agents that might promote oral health using a selective battery of in vitro and animal tests. Secondary objectives include the development of testing procedures. Recent studies indicate that the anticaries benefits of the intraoral fluoride releasing device can be improved if the teeth are pretreated with a calcium phosphate solution developed by Chow and coworkers (1974). We have identified mechanisms that might contribute to therapeutic effects of the antiplaque agents, alexidine and octenidine. We have developed an in vivo method for measuring the pH of rat plaque in situ.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000112-15
Application #
3939904
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code