Previous in vitro and in vivo studies have shown that an intraoral fluoride-releasing device developed by the Southern Research Institute for the National Institute of Dental Research will deliver fluoride at a steady rate for up to six months. This project will evalute the anticaries effect and mechanisms of action of the fluoride-releasing device in rats. Results have shown that rats that had an intraoral fluoride-releasing device in their mouth developed significantly fewer caries on all surfaces than untreated or placebo treated animals. The data indicate that the marked caries reduction produced by the fluoride-releasing device was due to topical effects of fluoride. Additional data suggest that the cariostatic effects of the intraoral fluoride-releasing device may persist for a significant time period after the device is removed from the mouth; therefore, intermittent, as well as continual use of an intraoral fluoride-releasing device may provide signficant protection from dental caries.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000282-06
Application #
4692625
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code