Abstract

Natural products small molecules biosynthesized primarily by microorganisms, fungi and invertebrates - are engendered with diverse chemical structures that give rise to a broad range of biological activities and account for the majority of currently used therapeutics. With an emphasis on marine invertebrates, we have identified several classes of novel marine natural products that potently inhibit tumor cell growth in vitro, and HIV-1 infection. By employing distinct but complementary HIV-1 assays, we demonstrated that mirabamides, glycosylated and halogenated depsipeptides, inhibit HIV-1 infection at the early stage of entry, and the activity profiles for the suite of depsipeptides provided new structure activity relationships for this class of compounds.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK031135-02
Application #
7734067
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2008
Total Cost
$443,788
Indirect Cost

  Institution

Name
National Institute of Diabetes and Digestive and Kidney Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Sclafani, Anthony; Vural, Austin S; Ackroff, Karen (2018) Profound differences in fat versus carbohydrate preferences in CAST/EiJ and C57BL/6J mice: Role of fat taste. Physiol Behav 194:348-355
Sclafani, Anthony (2018) From appetite setpoint to appetition: 50years of ingestive behavior research. Physiol Behav 192:210-217
Sclafani, Anthony; Ackroff, Karen (2017) Flavor preferences conditioned by nutritive and non-nutritive sweeteners in mice. Physiol Behav 173:188-199
Davison, Jack R; Lohith, Katheryn M; Wang, Xiaoning et al. (2017) A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter. Antimicrob Agents Chemother 61:
Sclafani, Anthony; Adamantidis, Antoine; Ackroff, Karen (2016) MCH receptor deletion does not impair glucose-conditioned flavor preferences in mice. Physiol Behav 163:239-244
Kraft, Tamar T; Huang, Donald; Lolier, Melanie et al. (2016) BALB/c and SWR inbred mice differ in post-oral fructose appetition as revealed by sugar versus non-nutritive sweetener tests. Physiol Behav 153:64-9
Ackroff, Karen; Sclafani, Anthony (2016) Maltodextrin and sucrose preferences in sweet-sensitive (C57BL/6J) and subsensitive (129P3/J) mice revisited. Physiol Behav 165:286-90
Sclafani, Anthony; Ackroff, Karen (2016) Operant licking for intragastric sugar infusions: Differential reinforcing actions of glucose, sucrose and fructose in mice. Physiol Behav 153:115-24
Sclafani, Anthony; Touzani, Khalid; Ackroff, Karen (2015) Intragastric fat self-administration is impaired in GPR40/120 double knockout mice. Physiol Behav 147:141-8
Sclafani, Anthony; Ackroff, Karen (2015) Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice. Physiol Behav 140:156-63

Showing the most recent 10 out of 31 publications