lnterferon-induced enzyme activities such as the oligo (2'5') adenylate synthetase, and the oligo (2'5') A phosphodiesterase are investigated with the goal of understanding their role in the action of interferon, the induction of interferon by double-stranded RNA and, perhaps, control of cell growth and differentiation. Analogs of the mediator of interferon action, 2-5A, are synthesized in order to define the relationship between oligonucleotide structure and binding to and activation of the 2-5A dependent endonuclease. The eventual goal is to understand the biological role of the 2-5A system and to explore the potential of exploitation of this system in chemotherapy.

Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1989
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code