Course Of Renal Disease In Type 2 Diabetes Mellitus

Nelson, Robert G.

Abstract

The purpose of this project is to determine the natural course of renal disease in type 2 diabetes mellitus in the Pima Indians and to identify the underlying pathogenetic mechanisms involved in the initiation and progression of renal disease in this type of diabetes. This project, in part, represents an extension of work previously reported as Project Number Z01 DK 69037. Glomerular function was measured initially over a 4-year period in 194 Pima Indians selected to represent stages in the development and progression of diabetic renal disease. Eighty-six of these subjects had type 2 diabetes and micro- or macroalbuminuria. Subjects underwent serial determinations of albuminuria and GFR. Many of these subjects continue to be followed and they have accumulated over 15 years of data on glomerular hemodynamic function in type 2 diabetes. Many of these subjects have also had kidney biopsies. Our efforts in the coming year will focus on the pathobiology of kidney disease. We wish to identify, in particular, the role of the glomerular podocyte in the development and progression of diabetic kidney disease.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK069063-11
• Application #: 7337549
• Study Section: (PECR)
• Support Year: 11
• Fiscal Year: 2006

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney
• Country: United States

Publications

Pavkov, Meda E; Mason, Clinton C; Bennett, Peter H et al. (2009) Change in the distribution of albuminuria according to estimated glomerular filtration rate in Pima Indians with type 2 diabetes. Diabetes Care 32:1845-50

Sanchez-Nino, Maria Dolores; Sanz, Ana Belen; Ihalmo, Pekka et al. (2009) The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol 20:353-62

Hanson, Robert L; Craig, David W; Millis, Meredith P et al. (2007) Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. Diabetes 56:975-83

Nelson, Robert G; Tuttle, Katherine R (2007) The new KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and CKD. Blood Purif 25:112-4

Looker, Helen C; Fagot-Campagna, Anne; Gunter, Elaine W et al. (2007) Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res Rev 23:193-201

Otu, Hasan H; Can, Handan; Spentzos, Dimitrios et al. (2007) Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy. Diabetes Care 30:638-43

Shultis, Wendy A; Weil, E Jennifer; Looker, Helen C et al. (2007) Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30:306-11

Nelson, Robert G; Tuttle, Katherine R (2006) NKF releases new KDOQI guidelines for diabetes and CKD. Nephrol News Issues 20:29

Pavkov, M E; Knowler, W C; Bennett, P H et al. (2006) Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians. Kidney Int 70:1840-6

Wolford, J K; Yeatts, K A; Red Eagle, A R et al. (2006) Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians. Diabet Med 23:367-76