Role Of Energy Expenditure And Food Intake In Body Weigh

Tataranni, P. Antonio

Abstract

The main aim of this project is to study the regulation of energy expenditure and energy intake in humans and identify metabolic risk factors of weight gain in children and adults. To assess resting energy expenditure we use indirect calorimetry (metabolic carts and respiratory chamber). To assess energy expenditure in free-living condition we use doubly labeled water DWL). To assess energy intake and eating behavior we use food frequency questionnaires, vending machines, and taste tests. To determine the neuroanatomical correlates of hunger, taste and satiation we use positron emission tomography (PET). In the past year we have: a) expanded the study of the heritability of physical activity level (PAL) to 100 pairs of twins; b) completed a collaborative study to validate diet and PAL questionnaires in 35 Native American children using DLW (data currently being analyzed); c) continued a study to characterize eating behavior in pre-pubertal offspring of diabetic mothers; d) continued a study to characterize eating behavior in adult Pima siblings (ongoing); e) conducted a PET study in individuals with Prader-Willi syndrome (ongoing)

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK069076-03
• Application #: 6673902
• Study Section: (PECR)
• Support Year: 3
• Fiscal Year: 2002

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney
• Country: United States

Publications

Salbe, Arline D; Weyer, Christian; Lindsay, Robert S et al. (2002) Assessing risk factors for obesity between childhood and adolescence: I. Birth weight, childhood adiposity, parental obesity, insulin, and leptin. Pediatrics 110:299-306

Del Parigi, Angelo; Gautier, Jean-Francois; Chen, Kewei et al. (2002) Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci 967:389-97

Vozarova, B; Weyer, C; Bogardus, C et al. (2002) Differences in oral temperature and body shape in two populations with different propensities for obesity. Ann N Y Acad Sci 967:516-21

Lindsay, Robert S; Cook, Valerie; Hanson, Robert L et al. (2002) Early excess weight gain of children in the Pima Indian population. Pediatrics 109:E33

Del Parigi, Angelo; Chen, Kewei; Salbe, Arline D et al. (2002) Tasting a liquid meal after a prolonged fast is associated with preferential activation of the left hemisphere. Neuroreport 13:1141-5

Del Parigi, Angelo; Chen, Kewei; Gautier, Jean-Francois et al. (2002) Sex differences in the human brain's response to hunger and satiation. Am J Clin Nutr 75:1017-22

Salbe, Arline D; Weyer, Christian; Harper, Inge et al. (2002) Assessing risk factors for obesity between childhood and adolescence: II. Energy metabolism and physical activity. Pediatrics 110:307-14

Gautier, J F; Del Parigi, A; Chen, K et al. (2001) Effect of satiation on brain activity in obese and lean women. Obes Res 9:676-84

Tschop, M; Weyer, C; Tataranni, P A et al. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-9

Weyer, C; Vozarova, B; Ravussin, E et al. (2001) Changes in energy metabolism in response to 48 h of overfeeding and fasting in Caucasians and Pima Indians. Int J Obes Relat Metab Disord 25:593-600