Phthalate esters are plasticizers incorporated into nearly all plastic materials. The biochemical and ultrastructural effects of di(2-ethylhexyl)phthalate (DEHP) and related chemicals are being studied to assess potential mechanisms of phthalate ester toxicity. Since DEHP and other phthalates are also male chemosterilants and teratogenic in mice, studies are being conducted to determine the role of zinc in the pathophysiology of these reproductive effects and to discern no-observed toxic effect levels.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021062-04
Application #
3965202
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1986
Total Cost
Indirect Cost
Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code