TCDD (dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin) is one of the most toxic chemicals known to man. Progressive weight loss and thymic atrophy are two of its most frequent toxic symptoms. The induction of cleft palate and hydronephrosis characterize the teratogenic response of mice to TCDD. Because of the sensitivity of this response, we decided to use teratogenicity to measure the interaction of TCDD and other compounds with which it occurs in the environment. Such chemicals include polychlorinated dibenzofurans, polychlorinated biophenyls, hormones such as thyroxins and hydrocortisone, and drugs. The effects on TCDD toxicity are dependent upon chemical structure and may support a mechanistic hypothesis of TCDD toxicity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021070-02
Application #
4693189
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code