The maximum mean body weights of rats attained during the course of two-year studies increased by about 20% from 1975 to 1985. Higher body weights will leads in increases in the incidences of mammary tumors, pituitary tumors, and possibly other tumors. Modification of diet may slow the growth and lower the maximum body weight attained which in turn, may decrease the incidences of spontaneous tumors. Lower protein diet may d(!crease the incidence and severity of kidney disease. The purpose of this study is to determine the feasibility of 13% protein and 20% fiber diet (NTP-90) in lowering the maximum body weight and decreasing the severity of nephrosis in rats and mice in comparison with high protein, low fiber NIH-07 diet. Groups of 60M+60F F344 rats and B6C3F1 mice will be fed NIH-07 or NTP-90 diet for two years. Body weights, feed consumption and clinical chemistry parameters will be determined at selected intervals. Tissues will be collected for evaluation of nonneoplastic and neoplastic changes at the end of the study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES021141-02
Application #
3855859
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code