We have collected data on over 3,000 pregnant women in two urban areas of Ukraine, a former Soviet republic, where pollution is reputedly high; we took placentas and breast milk from 2,200 of them during delivery and hospitalization. We have been analyzing these data and have now published findings on all the pollutants that were studied. In general, the toxicants appear at such low levels in this sample, in spite of reports of high pollution, that the effect on reproductive outcomes cannot be addressed.. However, we have described the outcome of pregnancy in this population, Sixty percent of all pregnancies were terminated. The rate of preterm birth in our sample is remarkably low, but this is ascribed to the high fetal death rate at low gestational ages, and the high prevalence of prematurity (the preterm rate is computed on live births only). Risk factors for preterm birth have been addressed in the two urban areas, and will continue with an examination of the rate of low birth weight.
| Little, R E; Gladen, Beth C; Birmingham, Karen et al. (2004) Preterm birth rates in Avon County, England, and urban Ukraine. Eur J Obstet Gynecol Reprod Biol 113:154-9 |
| Gladen, Beth C; Shkiryak-Nyzhnyk, Zoreslava A; Chyslovska, Nataliya et al. (2003) Persistent organochlorine compounds and birth weight. Ann Epidemiol 13:151-7 |
| Little, Ruth E; Zadorozhnaja, Tamara D; Hulchiy, Olesya P et al. (2003) Placental weight and its ratio to birthweight in a Ukrainian city. Early Hum Dev 71:117-27 |
| Little, Ruth E; Northstone, Kate; Golding, Jean et al. (2002) Alcohol, breastfeeding, and development at 18 months. Pediatrics 109:E72-2 |
| Sasco, Annie J; Laforest, Laurent; Benhaim-Luzon, Veronique et al. (2002) Smoking and its correlates among preadolescent children in France. Prev Med 34:226-34 |
| Monaghan, S C; Little, R E; Hulchiy, O et al. (2001) Risk factors for spontaneous preterm birth in two urban areas of Ukraine. Paediatr Perinat Epidemiol 15:123-30 |
| Little, R E; Little, A S; Chislovska, N et al. (2001) Hospital admissions during pregnancy in two urban areas of Ukraine. Paediatr Perinat Epidemiol 15:323-7 |
| Zadorozhnaja, T D; Little, R E; Miller, R K et al. (2000) Concentrations of arsenic, cadmium, copper, lead, mercury, and zinc in human placentas from two cities in Ukraine. J Toxicol Environ Health A 61:255-63 |
| Monaghan, S C; Little, R E; Hulchiy, O et al. (2000) Preterm birth in two urban areas of Ukraine. Obstet Gynecol 95:752-5 |
| Gladen, B C; Zadorozhnaja, T D; Chislovska, N et al. (2000) Polycyclic aromatic hydrocarbons in placenta. Hum Exp Toxicol 19:597-603 |
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