Abstract

Accomplishments: We examined ovarian cancer risk in relation to use of phenolphthalein-containing laxatives in 410 epithelial ovarian cancer cases and 713 controls. Compared to women who never used a laxative, ever use of a phenolphthalein-containing laxative was not associated (OR 1.1, 95% CI 0.9 !1.4) with an increased risk of ovarian cancer. Risk was slightly higher with more frequent use (OR 1.2 for 75 or more days of use). When women who used non-phenolphthalein containing laxatives was used as the reference group, the associations were slightly larger: OR 1.4 for any use of phenolphthalein-containing laxatives and OR 1.5 for 75 or more days of use.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES049026-04
Application #
6432331
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Farr, Sherry L; Cai, Jianwen; Savitz, David A et al. (2006) Pesticide exposure and timing of menopause: the Agricultural Health Study. Am J Epidemiol 163:731-42
Cooper, Glinda S; Klebanoff, Mark A; Promislow, Joanne et al. (2005) Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology 16:191-200
Cooper, Glinda S; Longnecker, Matthew P; Peters, Ruth K (2004) Ovarian cancer risk and use of phenolphthalein-containing laxatives. Pharmacoepidemiol Drug Saf 13:35-9
Farr, S L; Cooper, G S; Cai, J et al. (2004) Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study. Am J Epidemiol 160:1194-204
Brett, Kate M; Cooper, Glinda S (2003) Associations with menopause and menopausal transition in a nationally representative US sample. Maturitas 45:89-97
Cooper, Glinda S; Savitz, David A; Millikan, Robert et al. (2002) Organochlorine exposure and age at natural menopause. Epidemiology 13:729-33
Cooper, Glinda S (2002) Hormone replacement following early menopause. JAMA 288:2824-5; author reply 2825
Cooper, G S; Longnecker, M P; Sandler, D P et al. (2000) Risk of ovarian cancer in relation to use of phenolphthalein-containing laxatives. Br J Cancer 83:404-6
Chie, W C; Hsieh, C; Newcomb, P A et al. (2000) Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol 151:715-22
Cooper, G S; Ephross, S A; Sandler, D P (2000) Menstrual patterns and risk of adult-onset diabetes mellitus. J Clin Epidemiol 53:1170-3

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