This project merges two previous projects into one. The two projects were Environmental and Genetic Factors in Lung Cancer (ES49017) and Magnetic fields, melatonin and breast cancer (ES49018). Both environmental and genetic factors are clearly implicated in cancer etiology. However, susceptibility is clearly important in determining the effect of environmental exposures. This project includes several studies. In lung cancer, there are two major studies. The first is a case-control study of genetic susceptibility to lung cancer in African-Americans and Caucasians in Los Angeles. I conducted this study while a faculty member at the University of Southern California. I have examined a large number of genetic polymorphisms relevant to lung cancer in this study. The study is of modest size by current standards, but is still valuable for examining common polymorphisms. In addition, I am participating in a collaborative study to pool across a number of lung cancer studies to provide sufficient power for studying gene-environment interactions. The second lung cancer study is a collaboration with a prospective cohort study of men in Shanghai, China. This study is based at the University of Southern California. I have been investigating genetic, dietary and environmental factors for lung cancer in this cohort for the past several years. I have done this work using what is called a nested-case control study design. This uses samples from all diagnosed cases of lung cancer and a matched set of controls from the cohort who have not developed cancer. The major strengths of this study are the prospective design and the unique exposures of the Shanghai Cohort. I have published prospective studies of a gene-diet interaction (isothiocyanates and GSTM1 polymorphism) and IGF-1 in relation to lung cancer in the Shanghai Cohort. The genetic studies have used DNA extracted from archival serum samples which presents logistic challenges. This extramurally funded study has recently been renewed for an additional five years of follow-up by NCI. I wrote the portions of the grant dealing with lung cancer. The lung cancer work that was funded includes studying interactions between selenium levels in serum and polymorphisms in selenoproteins and another study of biomarkers of aflatoxin intake in interaction with polymorphisms in DNA repair genes. I will be conducting these two studies using extramural funds. The other component project is a study of magnetic field exposure and breast cancer risk. This is a nested case-control study that I began with extramural funding while a faculty member at USC. From NIEHS, I continued to run this project until the completion of data collection. The main paper from the study was recently accepted for publication. This study was unusual in the prospective design and the inclusion of a predominantly minority populations. The results were negative regarding hazards of residential magnetic field exposure. Given the strong design, these findings should provide reassurance to the public regarding this ubiquitous exposure. In other breast cancer research, I am also a collaborator on the Sister Study having been involved in the initial concept.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES101574-01
Application #
6828633
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2003
Total Cost
Indirect Cost
Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Raimondi, S; Paracchini, V; Autrup, H et al. (2006) Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review. Am J Epidemiol 164:1027-42
Raimondi, Sara; Boffetta, Paolo; Anttila, Sisko et al. (2005) Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res 592:45-57
London, Stephanie J; Pogoda, Janice M; Hwang, Katherine Liao et al. (2003) Residential magnetic field exposure and breast cancer risk: a nested case-control study from a multiethnic cohort in Los Angeles County, California. Am J Epidemiol 158:969-80
Lee, Won Jin; Brennan, Paul; Boffetta, Paolo et al. (2002) Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review. Biomarkers 7:230-41
Benhamou, Simone; Lee, Won Jin; Alexandrie, Anna-Karin et al. (2002) Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis 23:1343-50
London, Stephanie J; Yuan, Jian-Min; Travlos, Gregory S et al. (2002) Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. J Natl Cancer Inst 94:749-54
Ursin, Giske; London, Stephanie; Yang, Dongyun et al. (2002) Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast Cancer Res Treat 72:139-43