Transmembrane Signaling Mechanisms

Birnbaumer, Lutz

Abstract

All non-sensory pertussis sensitive G proteins have been inactivated in mice in prior years by gene targeting. Gi2-/- mice develop ulcerative colitis, Go-/- mice develop a turning syndrome. During this year we concentrated on breeding the Gi2 mutation into mice a proper background to allow us to map susceptibility genes responsible for lack of ulcerative colitis in C57BL/6J mice but make it 100% penetrant in 129Sv mice. In collaborative studies we found that Go alpha counteracts the positive effects of cAMP in neurite outgrowth and on N-type Ca channel synthesis.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES101643-01
• Application #: 6828645
• Study Section: (LST)
• Support Year: 1
• Fiscal Year: 2003

Institution

• Name: U.S. National Inst of Environ Hlth Scis
• Country: United States

Publications

Marshall, John; Zhou, Xiao-Zhong; Chen, Gang et al. (2018) Antidepression action of BDNF requires and is mimicked by G?i1/3 expression in the hippocampus. Proc Natl Acad Sci U S A 115:E3549-E3558

Bissinger, Rosi; Lang, Elisabeth; Ghashghaeinia, Mehrdad et al. (2016) Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit G?i2. Sci Rep 6:30925

Choi, Jung-Mi; Kim, Sung-Soo; Choi, Chan-Il et al. (2016) Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice. Proc Natl Acad Sci U S A 113:10974-9

Xu, Ying; Orlandi, Cesare; Cao, Yan et al. (2016) The TRPM1 channel in ON-bipolar cells is gated by both the ? and the ?? subunits of the G-protein Go. Sci Rep 6:20940

Li, Xianjing; Wang, Duowei; Chen, Zhen et al. (2015) G?i1 and G?i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1. Proc Natl Acad Sci U S A 112:4731-6

Birnbaumer, Lutz (2015) From GTP and G proteins to TRPC channels: a personal account. J Mol Med (Berl) 93:941-53

Devanathan, Vasudharani; Hagedorn, Ina; Köhler, David et al. (2015) Platelet Gi protein G?i2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A 112:6491-6

Pérez-Gómez, Anabel; Bleymehl, Katherin; Stein, Benjamin et al. (2015) Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus. Curr Biol 25:1340-6

Keller, Kirsten; Maass, Martina; Dizayee, Sara et al. (2015) Lack of G?i2 leads to dilative cardiomyopathy and increased mortality in ?1-adrenoceptor overexpressing mice. Cardiovasc Res 108:348-56

Villanueva, Hugo; Visbal, Adriana P; Obeid, Nadine F et al. (2015) An essential role for G?(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Sci Signal 8:ra92