Transmembrane Signaling through Voltage-gated Ca Channel

Birnbaumer, Lutz

Abstract

The importance of a serine in the selectivity pore of the cardiac Ca channel was studied and shown to be essential for survival after excision as well as for activation by a dihydropyridine (Bay K8644). The data imply existence of an essential phosphorylation site of unknown location.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Intramural Research (Z01)
• Project #: 1Z01ES101683-01
• Application #: 6828648
• Study Section: (LST)
• Support Year: 1
• Fiscal Year: 2003

Institution

• Name: U.S. National Inst of Environ Hlth Scis
• Country: United States

Publications

Birnbaumer, Lutz (2007) The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding. Biochim Biophys Acta 1768:756-71

Birnbaumer, Lutz (2007) Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers. Biochim Biophys Acta 1768:772-93

Erxleben, Christian; Liao, Yanhong; Gentile, Saverio et al. (2006) Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Proc Natl Acad Sci U S A 103:3932-7

Erxleben, Christian; Gomez-Alegria, Claudio; Darden, Thomas et al. (2003) Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop. Proc Natl Acad Sci U S A 100:2929-34

Foerster, Katharina; Groner, Ferdi; Matthes, Jan et al. (2003) Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors. Proc Natl Acad Sci U S A 100:14475-80