Abstract

Multiple forms of TRPC2 mRNA were characterized clarifying differences among laboratories. The intron-exon structure of the TRP superfamily of cation channels summarized in a review. The recombinant TRPC3 expressed in HEK cells was evaluated for its sensitivity to activation by IP3 receptor and found not to be affected. This opens the question as to what previous data showing TRP-interacting peptides of the IP3 receptor affect capacitative calcium entry. Further delineation of this recently discovered class of cation channels is proposed to be obtained from studying mice with targetted disruption of the relevant genes. Two already exist.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES101684-01
Application #
6828649
Study Section
(LST)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Hou, Xin; Xiao, Haitao; Zhang, Yanhong et al. (2018) Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis 9:1015
Gao, Xinghua; Cao, Qiuhua; Cheng, Yan et al. (2018) Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc Natl Acad Sci U S A 115:E2960-E2969
Chauhan, Arun; Sun, Yuyang; Sukumaran, Pramod et al. (2018) M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. iScience 8:85-102
Sonoda, Takuma; Lee, Seul Ki; Birnbaumer, Lutz et al. (2018) Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits. Neuron 99:754-767.e4
Marcott, Pamela F; Gong, Sheng; Donthamsetti, Prashant et al. (2018) Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. Neuron 98:575-587.e4
He, Xiju; Li, Shoutian; Liu, Benju et al. (2017) Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Proc Natl Acad Sci U S A 114:E4582-E4591
Liu, Benju; He, Xiju; Li, Shoutian et al. (2017) Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGF?1 signaling pathway. Am J Transl Res 9:5619-5630
Belkacemi, Thabet; Niermann, Alexander; Hofmann, Laura et al. (2017) TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia 65:1535-1549
Wu, Yueh-Lin; Xie, Jian; An, Sung-Wan et al. (2017) Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. Kidney Int 91:830-841
Chen, Xiaoyun; Lu, Min; He, Xiju et al. (2017) TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-?B Translocation. Mol Neurobiol 54:7555-7566

Showing the most recent 10 out of 79 publications