The interstitial lung disease project seeks to uncover the genetic and environmental determinants of interstitial lung disease (ILD). Our ongoing effort to establish human disease/environmental exposure DNA collections, coupled with high-throughput resequencing, high-throughput genotyping, gene expression analysis by means of microarray, and Serial Analysis of Gene E Expression (SAGE) will allow us to explore relationships between specific environmental exposures and candidate susceptibility genes.
Seibold, Max A; Wise, Anastasia L; Speer, Marcy C et al. (2011) A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364:1503-12 |
Garantziotis, Stavros; Hollingsworth, John W; Ghanayem, Rami B et al. (2007) Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury. J Immunol 179:4187-92 |
Yang, Ivana V; Burch, Lauranell H; Steele, Mark P et al. (2007) Gene expression profiling of familial and sporadic interstitial pneumonia. Am J Respir Crit Care Med 175:45-54 |
Lynch, David A; David Godwin, J; Safrin, Sharon et al. (2005) High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Am J Respir Crit Care Med 172:488-93 |
Burch, Lauranell H; Schwartz, David A (2005) Finding fibrosis genes: the lung. Methods Mol Med 117:293-313 |
King Jr, Talmadge E; Safrin, Sharon; Starko, Karen M et al. (2005) Analyses of efficacy end points in a controlled trial of interferon-gamma1b for idiopathic pulmonary fibrosis. Chest 127:171-7 |
Steele, Mark P; Speer, Marcy C; Loyd, James E et al. (2005) Clinical and pathologic features of familial interstitial pneumonia. Am J Respir Crit Care Med 172:1146-52 |
Martinez, Fernando J; Safrin, Sharon; Weycker, Derek et al. (2005) The clinical course of patients with idiopathic pulmonary fibrosis. Ann Intern Med 142:963-7 |
Strieter, Robert M; Starko, Karen M; Enelow, Richard I et al. (2004) Effects of interferon-gamma 1b on biomarker expression in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 170:133-40 |
Garantziotis, Stavros; Steele, Mark P; Schwartz, David A (2004) Pulmonary fibrosis: thinking outside of the lung. J Clin Invest 114:319-21 |