Vitreous fluorophotometry was performed in patients with diabetes mellitus without retinopathy, patients with diabetes mellitus with nonproliferative retinopathy, and normal volunteer subjects, age- and sex-matched to the patients. A new method for evaluating blood-retinal barrier permeability to fluorescein and diffusivity of fluorescein in the vitreous was developed. The amount of fluorescein leakage into the vitreous of patients was compared to that of the normal subjects. Correlations with other features of diabetes, such as the quality of diabetic control, the existence of subclinical neuropathy and nephropathy, and other complications were sought.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000162-08
Application #
3898135
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code