In diabetes, the incidence and progression of complications associated with hyperglycemia have been linked to the production of sugar alcohols (polyols). The relationship between aldose reductase, other closely related NADPH-dependent reductases, and polyol production is being investigated to define the biochemical mechanism(s) that initiate the onset of these complications and to develop specific pharmacological methods of intervention.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Intramural Research (Z01)
Project #
1Z01EY000275-01
Application #
3841245
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
United States
Zip Code